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CXCR2-mediated recruitment of adaptive NK cells with NKG2C/HLA-E dependent antigen-specific memory enhances tumor killing in ovarian cancer

2024-03-31

Abstract excerpt

Natural killer (NK) cells have emerged as promising effectors in cancer immunotherapy due to their ability to recognize and eliminate tumor cells. To investigate the immunological memory and tumor reactivity of adaptive (a)NK cells in the context of desmoplastic tumors, we used human ovarian cancer as a model. Through in vitro culture systems resembling dendritic cell (DC)-mediated T cell activation, we demonstra...

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Literature Corpus work
0dc5c41a-00cd-5287-9ade-961b820d02c2
DOI
10.1101/2024.03.28.585607
Open publication

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CXCR2-mediated recruitment of adaptive NK cells with NKG2C/HLA-E dependent antigen-specific memory enhances tumor killing in ovarian cancerDOI 10.1101/2024.03.28.585607
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