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Article

Genetics and causality of triglyceride-rich lipoproteins in atherosclerotic cardiovascular disease.

Journal of the American College of Cardiology - 16 Dec 2014

Rosenson Robert S, Davidson Michael H, Hirsh Benjamin J, Kathiresan Sekar, Gaudet Daniel

Abstract excerpt

Triglycerides represent 1 component of a heterogeneous pool of triglyceride-rich lipoproteins (TGRLs). The reliance on triglycerides or TGRLs as cardiovascular disease (CVD) risk biomarkers prompted investigations into therapies that lower plasma triglycerides as a means to reduce CVD events. Genetic studies identified TGRL components and pathways involved in their synthesis and metabolism. We advocate that only...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25500239
DOI: 10.1016/j.jacc.2014.09.042

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