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Article

Hypoxia promotes airway differentiation in the human lung epithelium

2024-08-09

Abstract excerpt

<h4>ABSTRACT</h4> Human early embryos develop under physiological hypoxia, but how hypoxia regulates human organogenesis remains little known. We have investigated oxygen availability effects on the human lung epithelium using organoids. We find first-trimester lung epithelial progenitors remain undifferentiated under normoxia, but spontaneously differentiate towards multiple airway cell types and inhibit alveola...

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Literature Corpus work
0d5d82d8-a063-541b-8460-ccfa665efea3
DOI
10.1101/2024.08.09.607336
Open publication

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Hypoxia promotes airway differentiation in the human lung epitheliumDOI 10.1101/2024.08.09.607336
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