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Article

Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2013

Shu Minfeng, Taddeo Brunella, Zhang Weiran, Roizman Bernard

Abstract excerpt

Herpes simplex virus 1 (HSV-1) encodes an endoribonuclease that is responsible for the shutoff of host protein synthesis [virion host shutoff (VHS)-RNase]. The VHS-RNase released into cells during infection targets differentially four classes of mRNAs. Thus, (a) VHS-RNase degrades stable cellular mRNAs and α (immediate early) viral mRNAs; (b) it stabilizes host stress response mRNAs after deadenylation and...

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Identifiers

PMID: 23589852
DOI: 10.1073/pnas.1305475110
PMCID: PMC3645526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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