Article
The epigenetically regulated miR-494 associates with stem-cell phenotype and induces sorafenib resistance in hepatocellular carcinoma.
Cell death & disease - 5 Jan 2018
Pollutri Daniela, Patrizi Clarissa, Marinelli Sara, Giovannini Catia, Trombetta Elena, Giannone Ferdinando A, Baldassarre Maurizio, Quarta Santina, Vandewynckel Y P, Vandierendonck A, Van Vlierberghe H, Porretti Laura, Negrini Massimo, Bolondi Luigi, Gramantieri Laura, Fornari Francesca
Abstract excerpt
Hepatocellular carcinoma (HCC) represents the second cause of cancer-related mortality worldwide and is associated with poor prognosis, especially in patients not amenable for curative treatments. The multi-kinase inhibitor sorafenib represents the first-line treatment option for advanced HCC; nevertheless, its effectiveness is limited due to tumor heterogeneity as well as innate or acquired drug resistance,...
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