Article

Presenilin-deficient neurons and astrocytes display normal mitochondrial phenotypes

2020-07-16

Abstract excerpt

Presenilins 1 and 2 (PS1 and PS2) are predominantly known as the catalytic subunits of the γ-secretase complex which generates the amyloid-β (Aβ) peptide, the major constituent of the senile plaques found in the brain of Alzheimer’s disease (AD) patients. Apart from their role in γ-secretase activity, a growing number of cellular functions have been recently attributed to PSs. They are involved in synaptic transmi...

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Literature Corpus work: 0d17ee8d-53be-5f1a-abad-e9e0faede540
DOI: 10.1101/2020.07.15.204255

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