Article

Cellular labeling of endogenous virus replication (CLEVR) reveals de novo insertions of the gypsy endogenous retrovirus in cell culture and in both neurons and glial cells of aging fruit flies

2018-10-16

Abstract excerpt

Evidence is rapidly mounting that transposable element expression and replication may impact biology more widely than previously thought. This includes potential effects on normal physiology of somatic tissues and dysfunctional impacts in diseases associated with aging such as cancer and neurodegeneration. Investigation of the biological impact of mobile elements in somatic cells will be greatly facilitated by use...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d0dd975-f734-50f3-8ff9-8cd0ae4c62af
DOI: 10.1101/445221

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cellular labeling of endogenous virus replication (CLEVR) reveals de novo insertions of the gypsy endogenous retrovirus in cell culture and in both neurons and glial cells of aging fruit fliesDOI 10.1101/445221Read

Intercellular viral spread and intracellular transposition of <i>Drosophila</i> gypsySemantic proximity Read

Expression of retrotransposons contributes to aging in <i>Drosophila</i>Semantic proximity Read

Morphological and molecular characterization of new Drosophila cell lines established from a strain permissive for gypsy transposition.Semantic proximity Read

Exploiting attP landing sites and gypsy retrovirus insulators to identify and study viral suppressors of RNA silencingSemantic proximity Read

Direct cell-to-cell transmission of retrotransposonsSemantic proximity Read

Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila.Semantic proximity Read

Two variants of the Drosophila melanogaster retrotransposon gypsy (mdg4): structural and functional differences, and distribution in fly stocks.Semantic proximity Read

An endogenous retroviral element co-opts an upstream regulatory sequence to achieve somatic expression and mobilitySemantic proximity Read

Drosophila germline invasion by the endogenous retrovirus gypsy: involvement of the viral env geneSemantic proximity Read

Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes.Semantic proximity Read

Retrovirus reactivation in CHMP2BIntron5 models of frontotemporal dementia.Semantic proximity Read

Molecular analysis of the gypsy (mdg4) retrotransposon in two Drosophila melanogaster strains differing by genetic instability.Semantic proximity Read