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Sex Chromosome-Informed High-Throughput Screening of Anti-Hypertrophic Drugs Using hESC-Derived Cardiomyocytes

2025-06-24

Abstract excerpt

<title>Abstract</title> <p>Cardiac hypertrophy is a major contributor to heart failure, with sex differences influencing disease progression and therapeutic responses. Utilizing XX (H9) and XY (HUES7) human embryonic stem cell (hESC) lines, we established a stepwise differentiation and replating protocol that generates high-purity cardiomyocytes (CMs), optimized for quantitative phenotyping and high-throughput sc...

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Literature Corpus work
0d004381-6556-5f82-9646-e413a72e77d9
DOI
10.21203/rs.3.rs-6911584/v1
Open publication

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