Article

NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma

2017-04-28

Abstract excerpt

Cancers display intratumoral genetic and molecular heterogeneity with tumor initiating cells (TIC) showing enhanced tumor phenotypes. In this study, we show the calcium pathway transcription factor NFATc2 is a novel regulator of lung TIC through the NFATc2/SOX2/ALDH1A1 regulatory axis. In vitro and in vivo cancer cell modeling demonstrated supportive evidences including cell renewal, tumorigenicity at limiting d...

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Literature Corpus work: 0ce72d42-d30b-54be-9411-adc4f764b80d
DOI: 10.1101/131987

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