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Article

NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma.

eLife - 24 Jul 2017

Xiao Zhi-Jie, Liu Jing, Wang Si-Qi, Zhu Yun, Gao Xu-Yuan, Tin Vicky Pui-Chi, Qin Jing, Wang Jun-Wen, Wong Maria Pik

Abstract excerpt

Tumor-initiating cells (TIC) are dynamic cancer cell subsets that display enhanced tumor functions and resilience to treatment but the mechanism of TIC induction or maintenance in lung cancer is not fully understood. In this study, we show the calcium pathway transcription factor NFATc2 is a novel regulator of lung TIC phenotypes, including tumorspheres, cell motility, tumorigenesis, as well as in vitro and in...

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Identifiers

PMID: 28737489
DOI: 10.7554/eLife.26733
PMCID: PMC5570574

Genes

SOX2

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NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma.PMID 28737489Read ↗

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