Article

Programmed electrical stimulation in human iPSC-derived cardiomyocytes reveals mechanisms of lethal arrhythmias in Calcium Release Deficiency Syndrome

2026-04-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Calcium release deficiency syndrome (CRDS) is a recently described inherited channelopathy caused by loss-of-function variants in RYR2 . Clinically, CRDS patients present with lethal ventricular arrhythmias which are not reproduced on exercise stress testing, unlike catecholaminergic polymorphic ventricular tachycardia. A hallmark trigger identified for CRDS mimics a long-b...

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Literature Corpus work: 0c97ef6a-ce1c-5882-b0ac-c0fe6f3c83cc
DOI: 10.64898/2026.04.09.717574

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