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Calcium Release Deficiency Syndrome: A New Inherited Arrhythmia Syndrome.

Cardiac electrophysiology clinics - 1 Sept 2023

Kallas Dania, Roberts Jason D, Sanatani Shubhayan, Roston Thomas M

Abstract excerpt

Calcium release deficiency syndrome (CRDS) is a newly described form of inherited arrhythmia caused by damaging loss-of-function variants in the cardiac ryanodine receptor (RyR2). Unlike the prototypical RyR2 gain-of-function channelopathy, known as catecholaminergic polymorphic ventricular tachycardia, patients with CRDS are predisposed to sudden death usually in the absence of any electrical abnormalities at...

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Identifiers

PMID: 37558302
DOI: 10.1016/j.ccep.2023.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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