In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells.

doi:10.1159/000335753

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Article

In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2011

Fatima Azra, Xu Guoxing, Shao Kaifeng, Papadopoulos Symeon, Lehmann Martin, Arnáiz-Cot Juan J, Rosa Angelo O, Nguemo Filomain, Matzkies Matthias, Dittmann Sven, Stone Susannah L, Linke Matthias, Zechner Ulrich, Beyer Vera, Hennies Hans Christian, Rosenkranz Stephan, Klauke Baerbel, Parwani Abdul S, Haverkamp Wilhelm, Pfitzer Gabriele, Farr Martin, Cleemann Lars, Morad Martin, Milting Hendrik, Hescheler Juergen, Saric Tomo

Abstract excerpt

BACKGROUND/AIMS: Induced pluripotent stem (iPS) cells generated from accessible adult cells of patients with genetic diseases open unprecedented opportunities for exploring the pathophysiology of human diseases in vitro. Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is an inherited cardiac disorder that is caused by mutations in the cardiac ryanodine receptor type 2 gene (RYR2) and is...

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PMID: 22178870
DOI: 10.1159/000335753
PMCID: PMC3709175

Genes

RYR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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