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Article

Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes.

EBioMedicine - 1 Oct 2020

Sleiman Yvonne, Souidi Monia, Kumar Ritu, Yang Ellen, Jaffré Fabrice, Zhou Ting, Bernardin Albin, Reiken Steve, Cazorla Olivier, Kajava Andrey V, Moreau Adrien, Pasquié Jean-Luc, Marks Andrew R, Lerman Bruce B, Chen Shuibing, Cheung Jim W, Evans Todd, Lacampagne Alain, Meli Albano C

Abstract excerpt

BACKGROUND: While mutations in the cardiac type 2 ryanodine receptor (RyR2) have been linked to exercise-induced or catecholaminergic polymorphic ventricular tachycardia (CPVT), its association with polymorphic ventricular tachycardia (PMVT) occurring at rest is unclear. We aimed at constructing a patient-specific human-induced pluripotent stem cell (hiPSC) model of PMVT occurring at rest linked to a single point...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Processing, Post-Translational

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Identifiers

PMID: 32980690
DOI: 10.1016/j.ebiom.2020.103024
PMCID: PMC7519379

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