Article
An hiPSC-CM approach for electrophysiological phenotyping of a patient-specific case of short-coupled TdP.
Stem cell research & therapy - 18 Dec 2024
van Ham Willem B, Meijboom Esmeralda E M, Ligtermoet Merel L, Monshouwer-Kloots Jantine, Riele Anneline S J M Te, Asselbergs Folkert W, van Rooij Eva, Bourfiss Mimount, van Veen Toon A B
Abstract excerpt
INTRODUCTION: A healthy young woman, age 26 without prior cardiac complications, experienced an out-of-hospital cardiac arrest caused by ventricular fibrillation (VF), which coincided with a fever. Comprehensive diagnostics including echo, CMR, exercise testing, and genetic sequencing, did not identify any potential cause. This led to the diagnosis of idiopathic VF and installment of an implantable cardioverter...
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