Article

Biological Constraint as a Cause of Aging

2022-05-16

Abstract excerpt

Aging rate differs greatly between species, indicating that the process of senescence is largely genetically determined. Senescence evolves in part due to antagonistic pleiotropy (AP), where selection favors gene variants that increase fitness earlier in life but promote pathology later. Identifying the biological mechanisms by which AP causes senescence is key to understanding the endogenous causes of aging and i...

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Literature Corpus work: 0c42cc84-cc5a-5e25-bc5b-9b7af9c408e3
DOI: 10.20944/preprints202205.0212.v1

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