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Article

GRK5 deficiency exaggerates inflammatory changes in TgAPPsw mice.

Journal of neuroinflammation - 3 Jun 2008

Li Longxuan, Liu Jun, Suo William Z

Abstract excerpt

BACKGROUND: Deficiency of membrane G-protein coupled receptor (GPCR) kinase-5 (GRK5) recently has been linked to early AD pathogenesis, and has been suggested to contribute to augmented microglial activation in vitro by sensitizing relevant GPCRs. However, GRK5 deficient mice did not show any signs of microgliosis, except for their moderate increase in axonal defects and synaptic degenerative changes during...

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Identifiers

PMID: 18522748
DOI: 10.1186/1742-2094-5-24
PMCID: PMC2442054

Genes

GRK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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