Article

Glycosylated extracellular matrix drives immune suppression by controlling T cell movement, macrophage phenotype, and macrophage-T cell crosstalk in triple negative breast cancer

2025-08-18

Abstract excerpt

<title>Abstract</title> <p>The tumor extracellular matrix (ECM) is increasingly recognized as a key driver of immune suppression and therapy resistance in cancer. However, the specific ECM components and mechanisms that create this immunosuppressive environment remain poorly understood, hindering the development of new therapies. Here, we focus on triple-negative breast cancer (TNBC), an aggressive and treatment-...

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Literature Corpus work: aaab0f03-79a5-5071-bfe3-d284fc960d81
DOI: 10.21203/rs.3.rs-7375429/v1

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