Article

Identification of novel variants, genes and pathways potentially linked to Parkinson’s disease using machine learning

2023-06-27

Abstract excerpt

There are 78 loci associated with Parkinson’s disease (PD) in the most recent genome-wide association study (GWAS), yet the specific genes driving these associations are mostly unknown. Herein, we aimed to nominate the top candidate gene from each PD locus, and identify variants and pathways potentially involved in PD. We trained a machine learning model to predict PD-associated genes from GWAS loci using genomic,...

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Literature Corpus work: 0bbfb15f-8153-591f-b893-b49f571dbc54
DOI: 10.1101/2023.06.20.23291658

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