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Metabolomic Profile of Genetic Liability to Type 2 Diabetes Among 125,000 Mexican Adults: A Mendelian Randomization Study.

Diabetes care - 1 May 2026

Bragg Fiona, Alegre-Diaz Jesus, Trichia Eirini, Torres Jason M, Baca Paulina, Garcilazo-Ávila Adrián, González-Carballo Carlos, Ramirez-Reyes Raul, Rivas Fernando, Aguilar-Ramirez Diego, Gnatiuc Friedrichs Louisa, Herrington William G, Hill Michael, Hubbard Tabitha, Vergara Alejandra, Wade Rachel, Collins Rory, Peto Richard, Berumen Jaime, Kuri-Morales Pablo, Tapia-Conyer Roberto, Emberson Jonathan R

Abstract excerpt

OBJECTIVE: The Mexican population experiences a notably high prevalence of type 2 diabetes (T2D) and high T2D-associated disease risks. We used targeted plasma nuclear magnetic resonance metabolomics data within a Mendelian randomization framework to characterize the metabolomic profile of genetically predicted liability to T2D in this population. RESEARCH DESIGN AND METHODS: Between 1998 and 2004, 50,000 men and...

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PMID: 41892798
DOI: 10.2337/dc25-2933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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