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Type 2 Diabetes, Metabolic Traits, and Risk of Heart Failure: A Mendelian Randomization Study.

Diabetes care - 1 Jul 2021

Mordi Ify R, Lumbers R Thomas, Palmer Colin N A, Pearson Ewan R, Sattar Naveed, Holmes Michael V, Lang Chim C

Abstract excerpt

OBJECTIVE: The aim of this study was to use Mendelian randomization (MR) techniques to estimate the causal relationships between genetic liability to type 2 diabetes (T2D), glycemic traits, and risk of heart failure (HF). RESEARCH DESIGN AND METHODS: Summary-level data were obtained from genome-wide association studies of T2D, insulin resistance (IR), glycated hemoglobin, fasting insulin and glucose, and HF. MR...

Topics

Diabetes Mellitus, Type 2
Genome-Wide Association Study
Heart Failure
Humans
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide
Risk Factors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34088700
DOI: 10.2337/dc20-2518
PMCID: PMC8323186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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