Article

Ex vivo effect of JAK inhibition on JAK-STAT1 pathway hyperactivation in patients with dominant negative STAT3 mutations

2022-02-17

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose</bold>: STAT1 gain-of-function (GOF) and dominant negative (DN) STAT3 syndromes share clinical manifestations including infectious and inflammatory manifestations. Targeted treatment with Janus-kinase (JAK) inhibitors show promising results in treating STAT1 GOF-associated symptoms whilst management of DN STAT3 patients has been largely supportive. We here assessed the imp...

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Literature Corpus work: 0b5b356b-5c4d-5220-90e9-de2f55244710
DOI: 10.21203/rs.3.rs-1346663/v1

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