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Article

Dysregulation of autophagy by HIV-1 Nef in human astrocytes

15 Jul 2015

Abstract excerpt

Viruses often exploit autophagy, a common cellular process of degradation of damaged proteins, organelles, and pathogens, to avoid destruction. HIV-1 dysregulates this process in several cell types by means of Nef protein. Nef is a small HIV-1 protein which is expressed abundantly in astrocytes of HIV-1-infected brains and has been suggested to have a role in the pathogenesis of HIV-Associated Neurocognitive...

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PMID: 26176554
DOI: 10.1080/15384101.2015.1069927

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