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Article

Impaired K+ binding to glial glutamate transporter EAAT1 in migraine.

Scientific reports - 24 Oct 2017

Kovermann Peter, Hessel Margarita, Kortzak Daniel, Jen Joanna C, Koch Johannes, Fahlke Christoph, Freilinger Tobias

Abstract excerpt

SLC1A3 encodes the glial glutamate transporter hEAAT1, which removes glutamate from the synaptic cleft via stoichiometrically coupled Na+-K+-H+-glutamate transport. In a young man with migraine with aura including hemiplegia, we identified a novel SLC1A3 mutation that predicts the substitution of a conserved threonine by proline at position 387 (T387P) in hEAAT1. To evaluate the functional effects of the novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29066757
DOI: 10.1038/s41598-017-14176-4
PMCID: PMC5654970

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