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Endothelial Dnmt3a controls placenta vascularization and function to support fetal growth

2022-07-29

Abstract excerpt

The fetoplacental capillary network is of vital importance for proper nourishment during early development. Inadequate maternal-fetal circulation has emerged as one of the main pathophysiological features of placental insufficiency. Meta-analysis of human placental endothelial cells (EC) revealed that downregulation of the de novo DNA methyltransferase 3A ( DNMT3A ) is associated with preeclampsia. However, mech...

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Literature Corpus work
0a6b59f0-0159-567d-a8c3-4bd507e885a9
DOI
10.1101/2022.07.28.501807
Open publication

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Endothelial Dnmt3a controls placenta vascularization and function to support fetal growthDOI 10.1101/2022.07.28.501807
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