Article

Reverse GWAS: Using Genetics to Identify and Model Phenotypic Subtypes

2018-10-17

Abstract excerpt

Recent and classical work has revealed biologically and medically significant subtypes in complex diseases and traits. However, relevant subtypes are often unknown, unmeasured, or actively debated, making automatic statistical approaches to subtype definition particularly valuable. We propose reverse GWAS (RGWAS) to identify and validate subtypes using genetics and multiple traits: while GWAS seeks the genetic bas...

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Literature Corpus work: 0a21fb7a-d316-502e-a754-27dafaa1ba6d
DOI: 10.1101/446492

Open publication

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