Article
Assessment of bidirectional relationships between 98 genera of the human gut microbiota and amyotrophic lateral sclerosis: a 2-sample Mendelian randomization study.
BMC neurology - 3 Jan 2022
Zhang Linjing, Zhuang Zhenhuang, Zhang Gan, Huang Tao, Fan Dongsheng
Abstract excerpt
BACKGROUND: Growing evidence suggests a mutual interaction between gut microbiome alterations and ALS pathogenesis. However, previous studies were susceptible to potential confounding factors and reverse causation bias, likely leading to inconsistent and biased results. OBJECTIVES: To decipher the potentially mutual relationship between gut microbiota and ALS, we used a bidirectional two-sample MR approach to...
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