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Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jan 2026

Vittorelli Nina, Gómez-Muñoz Cintia, Andriushchenko Irina, Ollivier Louis, Agier Nicolas, Delmas Stéphane, Corbeau Yann, Achaz Guillaume, Cosentino Lagomarsino Marco, Liti Gianni, Llorente Bertrand, Fischer Gilles

Abstract excerpt

Evolutionary transitions in mating strategy have profound consequences for genetic variation and adaptation. In Saccharomyces cerevisiae, mating-type switching is a central feature of the life cycle that enables haploid cells to be self-fertile and mate with their own mitotic descendants (homothallism). Yet heterothallic isolates that have lost this ability are found across diverse niches, indicating that this...

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PMID: 41499393
DOI: 10.1073/pnas.2525679123
PMCID: PMC12799175

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