Article

Rat somatic genome editing enables ER+ breast cancer modeling

2025-09-18

Abstract excerpt

Genetically engineered mouse models have advanced cancer research but often fail to capture key features of certain human tumors. Rats, with distinct physiology and tumor biology, offer a powerful alternative, yet their use has been constrained by technical barriers to genome editing. Here, we report efficient somatic genome editing in rats, enabling both Indel and substitution mutations. We then apply this approa...

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Literature Corpus work: 09cc16e6-4505-53f1-bf53-d4bd92421f92
DOI: 10.1101/2025.09.15.675961

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