Article

Homologous recombination deficiency in primary ER-positive and HER2-negative breast cancer

2025-06-04

Abstract excerpt

<h4>ABSTRACT</h4> Homologous recombination deficiency (HRD) originating from inactivation of genes like BRCA1 / BRCA2 is a targetable abnormality common in triple-negative breast cancer (TNBC). In estrogen-receptor (ER)-positive HER2-negative (ERpHER2n) breast cancer (BC), HRD prevalence and clinical impact are unclear. We analyzed 502 ERpHER2n tumors from patients recruited via the population-representative Swedi...

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Literature Corpus work: 09bce638-1236-56ba-8605-4e9f04dce9c7
DOI: 10.1101/2025.06.04.25328880

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