Article

Charting the Spatial Transcriptome of the Human Cerebral Cortex at Single-Cell Resolution

2024-01-31

Abstract excerpt

In our pursuit of creating a comprehensive human cortical atlas to understand human intelligence, we examined the single-nuclei transcriptomes of 307,738 cells alongside spatial transcriptomics data from 46,948 VISIUM spots and 1,355,582 Stereo cells. Atlases reveal distinct expression patterns and spatial arrangements of cortical neural cell types. Glutamatergic neurons exhibit precise laminar patterns, often mir...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f300cade-1e9f-5684-92fc-f3fe67c88ad9
DOI: 10.1101/2024.01.31.576150

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Charting the Spatial Transcriptome of the Human Cerebral Cortex at Single-Cell ResolutionDOI 10.1101/2024.01.31.576150Read

A Population-scale Single-cell Spatial Transcriptomic Atlas of the Human CortexSemantic proximity Read

Transcriptomic cytoarchitecture reveals principles of human neocortex organizationSemantic proximity Read

Single-cell multiomic human brain atlas reveals regulatory drivers of cortical regionalitySemantic proximity Read

Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neuronsSemantic proximity Read

Human Neocortical Glutamatergic Neurons Revealed Through Multimodal ProfilingSemantic proximity Read

Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortexSemantic proximity Read

Conservation and divergence in cortical cellular organization between human and mouse revealed by single-cell transcriptome imagingSemantic proximity Read

Single-Cell Atlas Uncovers Layer 4 Heterogeneity and Functional Gradients in Rhesus Macaque Visual CortexSemantic proximity Read

Conserved cell types with divergent features between human and mouse cortexSemantic proximity Read

Comprehensive in situ mapping of human cortical transcriptomic cell typesSemantic proximity Read

Multiscale Spatial Transcriptomic Atlas of Human Basal Ganglia Cell-Type and Cellular Community OrganizationSemantic proximity Read

A multimodal cell census and atlas of the mammalian primary motor cortexSemantic proximity Read