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Article

Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia.

Journal of psychiatry & neuroscience : JPN - 1 Apr 2016

García-Bueno Borja, Gassó Patricia, MacDowell Karina S, Callado Luis F, Mas Sergi, Bernardo Miguel, Lafuente Amalia, Meana J Javier, Leza Juan C

Abstract excerpt

BACKGROUND: Alterations in the innate immune/inflammatory system may underlie the pathophysiology of schizophrenia, but we do not understand the mechanisms involved. The main agents of innate immunity are the Toll-like receptors (TLRs), which detect molecular patterns associated with damage and pathogens. The TLR first reported was TLR4, and it is still the most studied one. METHODS: We aimed to describe putative...

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Identifiers

PMID: 27070349
DOI: 10.1503/jpn.150195
PMCID: PMC4853215

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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