Article

PTBP1 is upregulated by Zika virus infection <i>via</i> HIF-1α signal and hijacks NS1 protein to induce NS1 degradation to restrain viral replication

2024-11-19

Abstract excerpt

Zika virus (ZIKV), belonging to the Flaviviridae family, has been a severe threat to human health since the worldwide outbreak. ZIKV is capable of inducing fetal microcephaly, Guillain-Barré syndrome, and other serious neurological complications. Polypyrimidine tract-binding protein 1 (PTBP1) is a key member of the heterogeneous nuclear ribonucleoproteins (hnRNPs) family, functioning in selective mRNA splicing an...

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Identifiers and source

Literature Corpus work: 096b82c3-70ff-5627-bac2-0819b8b83c34
DOI: 10.1101/2024.11.19.624259

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