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Zika virus disrupts molecular fingerprinting of human neurospheres

23 Jan 2017

Abstract excerpt

Zika virus (ZIKV) has been associated with microcephaly and other brain abnormalities; however, the molecular consequences of ZIKV to human brain development are still not fully understood. Here we describe alterations in human neurospheres derived from induced pluripotent stem (iPS) cells infected with the strain of Zika virus that is circulating in Brazil. Combining proteomics and mRNA transcriptional...

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PMID: 28112162
DOI: 10.1038/srep40780

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