Article
Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice.
EMBO molecular medicine - 1 Apr 2009
Li Hong Hua, Roy Madhuri, Kuscuoglu Unsal, Spencer Corinne M, Halm Birgit, Harrison Katharine C, Bayle Joseph H, Splendore Alessandra, Ding Feng, Meltzer Leslie A, Wright Elena, Paylor Richard, Deisseroth Karl, Francke Uta
Abstract excerpt
The neurodevelopmental disorder Williams-Beuren syndrome is caused by spontaneous approximately 1.5 Mb deletions comprising 25 genes on human chromosome 7q11.23. To functionally dissect the deletion and identify dosage-sensitive genes, we created two half-deletions of the conserved syntenic region on mouse chromosome 5G2. Proximal deletion (PD) mice lack Gtf2i to Limk1, distal deletion (DD) mice lack Limk1 to...
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