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Blocking glutamine transport normalizes lymphatic vessels in hypoxic environments by attenuating glycolysis

2025-12-22

Abstract excerpt

Dysfunctional lymphangiogenesis is a component of several diseases, including secondary lymphedema, allergic asthma, and solid malignancies. These vessels are ineffective at draining interstitial fluid, resulting in secondary complications such as edema, increased inflammation, slowed wound healing, and, for cancer patients, increased risk of metastasis. Hypoxic microenvironments drive dysfunctional vessel growth...

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Literature Corpus work
09228b3d-29ca-5fec-8b84-4ac312dcb676
DOI
10.64898/2025.12.18.695240
Open publication

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Blocking glutamine transport normalizes lymphatic vessels in hypoxic environments by attenuating glycolysisDOI 10.64898/2025.12.18.695240
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