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Article

Structural basis of peptidoglycan endopeptidase regulation.

Proceedings of the National Academy of Sciences of the United States of America - 26 May 2020

Shin Jung-Ho, Sulpizio Alan G, Kelley Aaron, Alvarez Laura, Murphy Shannon G, Fan Lixin, Cava Felipe, Mao Yuxin, Saper Mark A, Dörr Tobias

Abstract excerpt

Most bacteria surround themselves with a cell wall, a strong meshwork consisting primarily of the polymerized aminosugar peptidoglycan (PG). PG is essential for structural maintenance of bacterial cells, and thus for viability. PG is also constantly synthesized and turned over; the latter process is mediated by PG cleavage enzymes, for example, the endopeptidases (EPs). EPs themselves are essential for growth but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32393643
DOI: 10.1073/pnas.2001661117
PMCID: PMC7261138

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