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Article

High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer's disease phenotypes in a large mixed-dementia cohort.

Molecular neurodegeneration - 17 Nov 2025

Gong Katherine, Timsina Jigyasha, Ali Muhammad, Chen Yike, Liu Menghan, Wang Ciyang, Pottier Cyril, Feld Geoffrey K, Heo Gyujin, S Benzinger Tammie L, Raji Cyrus A, Ances Beau, Gordon Brian A, Wisch Julie K, Schindler Suzanne E, Morris John C, Holtzman David M, Ibanez Laura, Cruchaga Carlos

Abstract excerpt

Novel plasma assays enabled accurate blood-based biomarkers for neurodegenerative diseases with minimally invasive options for clinical use. Large-scale studies encompassing multiple neurodegenerative diseases using novel multiplex platforms are essential to uncover disease-specific biomarkers and pathways. We generated and analyzed plasma biomarker data using the NULISAseq™ CNS Panel from 3,232 participants with...

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Identifiers

PMID: 41250190
DOI: 10.1186/s13024-025-00909-x
PMCID: PMC12625197

Genes

FLT1
MSLN
PARK7
SAA1

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