Article

Microvesicles Transfer Mitochondria and Increase Mitochondrial Function in Brain Endothelial Cells

2021-04-11

Abstract excerpt

We have demonstrated, for the first time that microvesicles, a sub-type of extracellular vesicles (EVs) derived from hCMEC/D3: a human brain endothelial cell (BEC) line transfer polarized mitochondria to recipient BECs in culture and to neurons in mice acute brain cortical and hippocampal slices. This mitochondrial transfer increased ATP levels by 100 to 200-fold (relative to untreated cells) in the recipient BECs...

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Literature Corpus work: 086d7656-b8b6-56cd-9191-5a20072bf0ae
DOI: 10.1101/2021.04.10.439214

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