Unveiling the role of miRNAs from MSC-EVs in neuroinflammation and behavioral impairments induced by chronic alcohol consumption

Abstract excerpt

<h4>ABSTRACT</h4> Extracellular vesicles derived from mesenchymal stromal cells (MSC-EVs) have emerged as a promising form of regenerative and immunomodulatory therapy; indeed, micro (mi)RNAs contained within MSC-EVs modulate target gene expression and impact disease-associated pathways. Chronic alcohol consumption results in neuroinflammation, brain damage, and impaired cognition; in this study, we asked whether...

Topics

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• Administration, Intranasal
• Amyloid beta-Peptides
• Brain-Derived Neurotrophic Factor
• Extracellular Vesicles
• Hippocampus
• Mesenchymal stem cell research
• Neurogenesis and neuroplasticity mechanisms
• Neuroinflammation and Neurodegeneration Mechanisms

Identifiers and source

Literature Corpus work

df0e6273-9837-57db-8f3a-bc8b22522fde

DOI

10.1101/2024.10.03.616225