Article

Interpretable deep learning for chromatin-informed inference of transcriptional programs driven by somatic alterations across cancers

2021-09-09

Abstract excerpt

Cancer is a disease of gene dysregulation, where cells acquire somatic and epigenetic alterations that drive aberrant cellular signaling. These alterations adversely impact transcriptional programs and cause profound changes in gene expression. Interpreting somatic alterations within context-specific transcriptional programs will facilitate personalized therapeutic decisions but is a monumental task. Toward this g...

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Literature Corpus work: 084d9a60-ac55-5da0-ab4f-bab015433290
DOI: 10.1101/2021.09.07.459263

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