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Expression and functional characterization of ABCG2 in brain endothelial cells and vessels

1 Sept 2003

Abstract excerpt

Delivery of drugs to the brain is impeded by the activity of efflux pumps expressed by endothelial cells of brain vasculature. The ATP binding cassette (ABC) transporters, among which ABCB1/MDR1 P-glycoprotein and ABCC1/multidrug resistance-associated protein 1 are expressed in brain endothelial cells, participate in drug efflux properties of the blood-brain barrier (BBB). Searches of the EST (expressed sequence...

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PMID: 12958161
DOI: 10.1096/fj.02-1131fje

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