Article

Leukocyte cytokine responses in adult patients with mitochondrial DNA defects

2021-12-16

Abstract excerpt

Patients with oxidative phosphorylation (OxPhos) defects causing mitochondrial diseases appear particularly vulnerable to infections. Although OxPhos defects modulate cytokine production in vitro and in animal models, little is known about how circulating leukocytes of patients with inherited mitochondrial DNA (mtDNA) defects respond to acute immune challenges. In a small cohort of healthy controls (n=21) and pat...

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Literature Corpus work: 07cfbd40-7bd3-542a-8ab1-8cfc824cb4b6
DOI: 10.1101/2021.12.13.472449

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