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QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration

2023-06-16

Abstract excerpt

<title>Abstract</title> <p>DNA methylation (DNAm) provides a crucial epigenetic mark linking genetic variations to environmental influence. We analyzed array-based DNAm profiles of 160 human retinas with co-measured RNA-seq and > 8 million genetic variants, uncovering sites of genetic regulation in <italic>cis</italic> (37,453 mQTLs and 12,505 eQTLs) and 13,747 eQTMs (DNAm loci affecting gene expression), with ov...

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Literature Corpus work
07bfcad0-d5ca-5213-aea2-7c4c3646cb61
DOI
10.21203/rs.3.rs-3011096/v1
Open publication

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QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degenerationDOI 10.21203/rs.3.rs-3011096/v1
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