Article

Sympathetic Signaling Activation in Macrophages Alleviates LPS-induced ARDS through the HDC-H1R-SLC7A11 Axis

2025-09-05

Abstract excerpt

<title>Abstract</title> <p>Acute respiratory distress syndrome (ARDS) is a life-threatening inflammatory lung disorder in which ferroptosis plays a critical role in promoting macrophage-mediated tissue injury. However, the upstream neuroimmune signals regulating ferroptosis remain unclear. Here, we demonstrate that norepinephrine (NE) significantly suppresses LPS-induced ferroptosis in alveolar macrophages (AMs)...

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Literature Corpus work: 7c0dda87-9b22-58da-a0da-fd02cfa8f3c3
DOI: 10.21203/rs.3.rs-6760807/v1

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