Article

Image-based phenotypic profiling of a chemogenomic screening library identifies novel druggable targets in the EGFR-pathway

2021-04-17

Abstract excerpt

<h4>Summary</h4> The gene encoding epidermal growth factor receptor (EGFR) is a major driver gene in cancer. Many drugs targeting EGFR-associated molecules have been developed, yet many have failed in clinical trials due to a lack of efficacy and/or unexpected side effects. In this study, I used image-based phenotypic profiling to screen a pharmacologically active compound library with the aim of identifying new...

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Literature Corpus work: 07a3dc26-91bd-56d0-86d8-a52d4439f59d
DOI: 10.1101/2021.04.16.440090

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