Article

Accelerated biological aging in people with Down syndrome with full and segmental trisomy 21 begins in childhood as revealed by immunoglobulin G glycosylation

2021-12-15

Abstract excerpt

<title>Abstract</title> <p>Cells from people with Down syndrome (DS) show faster accumulation of DNA damage and epigenetic aging marks. Causative mechanisms remain un-proven and hypotheses range from amplified chromosomal instability to actions of several supernumerary chromosome 21 genes. Plasma immunoglobulin G (IgG) glycosylation profiles are established as a reliable predictor of biological and chronological...

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Literature Corpus work: 076d59ba-eed3-59de-9ca6-fe87ae1afa9f
DOI: 10.21203/rs.3.rs-1128079/v1

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