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Cholera toxin-induced disease generates epithelial cell-derived L-lactate that promotes <i>Vibrio cholerae</i> growth in the small intestine

2025-08-13

Abstract excerpt

<h4>SUMMARY</h4> Cholera toxin (CT) promotes Vibrio cholerae colonization by altering gut metabolism to favor pathogen growth. We have previously found that CT-induced disease leads to increased concentrations of L-lactate in the lumen of the small intestine during experimental cholera. Here, we show that CT-induced disease leads to the upregulation of mammalian lactate dehydrogenase A (LDHA), an enzyme that cat...

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Literature Corpus work
07485239-8619-5212-96ce-7c77f84d1f52
DOI
10.1101/2025.08.12.669941
Open publication

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Cholera toxin-induced disease generates epithelial cell-derived L-lactate that promotes <i>Vibrio cholerae</i> growth in the small intestineDOI 10.1101/2025.08.12.669941
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