Article

A clinically-relevant polymorphism in the Na <sup>+</sup> /taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position

2020-07-03

Abstract excerpt

Conventionally, most amino acid substitutions at important protein positions are expected to abolish function. However, in several soluble-globular proteins, we identified a class of non-conserved positions for which various substitutions produced progressive functional changes; we consider these evolutionary “rheostats”. Here, we report a strong rheostat position in the integral membrane protein, Na + /taurochol...

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Literature Corpus work: 07326623-bd16-5709-b6ee-9cf75e84e5b7
DOI: 10.1101/2020.07.02.184424

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