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Article

Structure-activity studies on arylamides and arysulfonamides Ras inhibitors.

Current cancer drug targets - 1 Mar 2010

Colombo Sonia, Palmioli Alessandro, Airoldi Cristina, Tisi Renata, Fantinato Sonia, Olivieri Sandro, De Gioia Luca, Martegani Enzo, Peri Francesco

Abstract excerpt

This paper reports the synthesis of a panel of small molecules with arylamides and arylsulfonamides groups and their biological activity in inhibiting nucleotide exchange on human Ras. The design of these molecules was guided by experimental and molecular modelling data previously collected on similar compounds. Aim of this work is the validation of the hypothesis that a phenyl hydroxylamine group linked to a...

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PMID: 20088786
DOI: 10.2174/156800910791054185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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